SCIENTIFIC SECTION DESIGNATION: NEOPLASIA CXCR4 expression and biological activity in acute myeloid leukemia are dependent on oxygen partial pressure Short title: CXCR4 expression and pO2 in AML
نویسندگان
چکیده
Michael Fiegl, Ismael Samudio, Karen Clise-Dwyer, Jared K. Burks, Zakar Mnjoyan, and Michael Andreeff Molecular Hematology & Therapy, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA; Department of Leukemia, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA M.F. and I.S. contributed equally to this work
منابع مشابه
MYELOID NEOPLASIA CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure
The CXCR4/SDF-1 axis has been studied extensively because of its role in development and hematopoiesis. In acute myeloid leukemia (AML), elevated expression of CXCR4 has been shown to correlate with shortened survival. Hypoxia increases CXCR4 in several tumor models, but the impact of reduced O2 partial pressure (pO2) on expression and biologic function of CXCR4 in AML is unknown. We determined...
متن کاملCXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure.
The CXCR4/SDF-1 axis has been studied extensively because of its role in development and hematopoiesis. In acute myeloid leukemia (AML), elevated expression of CXCR4 has been shown to correlate with shortened survival. Hy-poxia increases CXCR4 in several tumor models, but the impact of reduced O(2) partial pressure (pO(2)) on expression and biologic function of CXCR4 in AML is unknown. We deter...
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